Hormone replacement therapy and the risk of breast cancer

被引：38

作者：

Cuzick, Jack ^{[1
]}

机构：

[1] Univ London, Wolfson Inst Prevent Med, Canc Res UK Ctr Epidemiol Math & Stat, London EC1M 6BQ, England

来源：

EUROPEAN JOURNAL OF CANCER | 2008年 / 44卷 / 16期

关键词：

Hormone replacement therapy; Breast cancer risk; Oestrogen therapy; Progestagens;

D O I：

10.1016/j.ejca.2008.07.041

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hormone replacement therapy (HRT) has had a chequered history ever since its initial use to manage menopausal symptoms. it is clear that it has many other effects and here we review its impact on the risk of breast cancer. A clear risk is seen for current uses of combined oestrogen/progestagen pills, but this returns to normal shortly after treatment cessation. The role of oestrogen only replacement therapy is less clear, but most studies find a weaker, but still positive, association in current users. Recent sharp reductions in HRT use have been correlated with declines in breast cancer incidence in the USA, but not so clearly elsewhere. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2344 / 2349

页数：6

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