Molecular, structural, and cellular biology of follitropin and follitropin receptor

被引：113

作者：

Dias, JA ^{[1
]}

Cohen, BD ^{[1
]}

Lindau-Shepard, B ^{[1
]}

Nechamen, CA ^{[1
]}

Peterson, AJ ^{[1
]}

Schmidt, A ^{[1
]}

机构：

[1] New York State Dept Hlth, Wadsworth Ctr, David Axelrod Inst Publ Hlth, Albany, NY 12208 USA

来源：

VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 64 | 2002年 / 64卷

关键词：

D O I：

10.1016/S0083-6729(02)64008-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Follitropin and the follitropin receptor are essential for normal gamete development in males and females. This review discusses the molecular genetics and structural and cellular biology of the follitropin/follitropin receptor system. Emphasis is placed on the human molecules when possible. The structure and regulation of the genes for the follitropin β subunit and the follitropin receptor is discussed. Control of systemic and cellular protein levels is explained. The structural biology of each protein is described, including protein structure, motifs, and activity relationships. Finally, the follitropin/follitropin receptor signal transduction system is discussed. © 2002.

引用

页码：249 / 322

页数：74

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