Mathematical modeling and sensitivity analysis of G1/S phase in the cell cycle including the DNA-damage signal transduction pathway

被引：32

作者：

Iwamoto, Kazunari ^{[1
]}

Tashima, Yoshihiko ^{[1
]}

Hamada, Hiroyuki ^{[1
]}

Eguchi, Yukihiro ^{[2
]}

Okamoto, Masahiro ^{[1
,2
]}

机构：

[1] Kyushu Univ, Lab Bioinformat, Grad Sch Syst Life Sci, Higashi Ku, Fukuoka 8128581, Japan

[2] Kyushu Univ, Div Bioproc Design, Bioarchitecture Ctr, Higashi Ku, Fukuoka 8128581, Japan

来源：

BIOSYSTEMS | 2008年 / 94卷 / 1-2期

关键词：

Cell cycle; G1/S phase; p53-Mdm2; oscillation; Numerical simulation;

D O I：

10.1016/j.biosystems.2008.05.016

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The cell cycle has checkpoint systems, which control G1/S, G2/M and G0/G1 phase transitions. When a normal cell suffers from DNA-damage, the signal transduction of DNA-damage causes the cell cycle arrest by using the checkpoint systems. Therefore, the elucidation of interaction between the signal transduction of DNA-damage and the checkpoint systems is an important problem. In this study, we constructed a novel mathematical model (proposed model) which integrated G1/S-checkpoint model with a signal transduction of DNA damage model and performed some numerical simulations. The proposed model realized some biological findings of G1/S phase with or without DNA-damage, which suggested that proposed model is biologically appropriate. Moreover, the results of sensitivity analysis of the proposed model indicated the predominant factors of G1/S phase and some factors concerned with the transformation of cells. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：109 / 117

页数：9

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