E2F target genes: unraveling the biology

被引：452

作者：

Bracken, AP

Ciro, M

Cocito, A

Helin, K ^{[1
]}

机构：

[1] European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy

[2] Biotech Res & Innovat Ctr, DK-2100 Copenhagen, Denmark

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2004年 / 29卷 / 08期

关键词：

D O I：

10.1016/j.tibs.2004.06.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The E2F transcription factors are downstream effectors of the retinoblastoma protein (pRB) pathway and are required for the timely regulation of numerous genes essential for DNA replication and cell cycle progression. Several laboratories have used genome-wide approaches to discover novel target genes of E2F, leading to the identification of several hundred such genes that are involved not only in DNA replication and cell cycle progression, but also in DNA damage repair, apoptosis, differentiation and development. These new findings greatly enrich our understanding of E2F controls transcription and cellular homeostasis.

引用

页码：409 / 417

页数：9

共 73 条

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