Color test for the detection of resin-bound aldehyde in solid-phase combinatorial synthesis

被引：24

作者：

Cournoyer, JJ ^{[1
]}

Kshirsagar, T ^{[1
]}

Fantauzzi, PP ^{[1
]}

Figliozzi, GM ^{[1
]}

Makdessian, T ^{[1
]}

Yan, B ^{[1
]}

机构：

[1] ChemRx Adv Technol, San Francisco, CA 94080 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2002年 / 4卷 / 02期

关键词：

D O I：

10.1021/cc010060g

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We report the development of a sensitive and specific color test for the detection of the presence of resin-bound aldehyde groups using 4-amino-3-hydrazino-5-mercapto-1,2,4-triazole (Purpald). Aldehyde resin turns dark-brown to purple after a 5 min reaction followed by a 10 min air oxidation period. Resins that possess other functional groups (i.e., ketone, ester, amide, alcohol, and carboxylic acid) do not change color under the same conditions. The detection limit is 20 mumol/g for polystyrene-based aldehyde resins.

引用

页码：120 / 124

页数：5

共 10 条

[1] Comprehensive survey of combinatorial library synthesis: 1999 [J].