Comparing language lateralization determined by dichotic listening and fMRI activation in frontal and temporal lobes in children with epilepsy

被引：41

作者：

Fernandes, MA ^{[1
]}

Smith, ML

Logan, W

Crawley, A

McAndrews, MP

机构：

[1] Univ Waterloo, Dept Psychol, Waterloo, ON N2L 3G1, Canada

[2] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[3] Toronto Western Hosp, Toronto, ON M5T 2S8, Canada

[4] Univ Toronto, Toronto, ON, Canada

来源：

BRAIN AND LANGUAGE | 2006年 / 96卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

language lateralization; children; epilepsy; dichotic listening; fMRI; temporal lobe; frontal lobe; localization; laterality index;

D O I：

10.1016/j.bandl.2005.06.006

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

We investigated the relationship between ear advantage scores on the Fused Dichotic Words Test (FDWT), and laterality of activation in fMR1 using a verb generation paradigm in fourteen children with epilepsy. The magnitude of the laterality index (U), based on spatial extent and magnitude of activation in classical language areas (BA 44/45, 21/22, 39) differed significantly for patients classified with unilateral left, compared to bilateral, language representation based on FDWT scores. Concordance with fMRI was higher for those classified with unilateral left, than bilateral language representation on the FDWT. Of note, asymmetry in temporal lobe, rather than frontal lobe, activation was more strongly related to the LI from the dichotic listening test. This study shows that the FDWT can provide a quick and valid estimate of lateralization in pre-surgical candidates, which can be readily adopted for other clinical or research purposes when an estimate of language dominance is desired. (c) 2005 Published by Elsevier Inc.

引用

页码：106 / 114

页数：9

共 45 条

[31] Cerebral lateralization of language in normal left-handed people studied by functional MRI [J].

Pujol, J ;

Deus, J ;

Losilla, JM ;

Capdevila, A .

NEUROLOGY, 1999, 52 (05) :1038-1043

[32] REPRESENTATIONS OF THE 2 EARS AT THE AUDITORY CORTEX [J].

ROSENZWEIG, MR .

AMERICAN JOURNAL OF PHYSIOLOGY, 1951, 167 (01) :147-158

[33] SEX-DIFFERENCES IN THE FUNCTIONAL-ORGANIZATION OF THE BRAIN FOR LANGUAGE [J].

SHAYWITZ, BA ;

SHAYWITZ, SE ;

PUGH, KR ;

CONSTABLE, RT ;

SKUDLARSKI, P ;

FULBRIGHT, RK ;

BRONEN, RA ;

FLETCHER, JM ;

SHANKWEILER, DP ;

KATZ, L ;

GORE, JC .

NATURE, 1995, 373 (6515) :607-609

[34]

Spreen O., 1991, PROFILE TEST RESULTS

[35] Language dominance in neurologically normal and epilepsy subjects - A functional MRI study [J].

Springer, JA ;

Binder, JR ;

Hammeke, TA ;

Swanson, SJ ;

Frost, JA ;

Bellgowan, PSF ;

Brewer, CC ;

Perry, HM ;

Morris, GL ;

Mueller, WM .

BRAIN, 1999, 122 :2033-2045

[36]

STRUPP JP, 1996, NEUROIMAGE, V1, P57

[37] Language lateralization in left-handed and ambidextrous people - fMR1 data [J].

Szaflarski, JP ;

Binder, JR ;

Possing, ET ;

McKiernan, KA ;

Ward, BD ;

Hammeke, TA .

NEUROLOGY, 2002, 59 (02) :238-244

[38]

Talairach J, 1988, CO PLANAR STEREOTAXI

[39] A functional MRI protocol for localizing language comprehension in the human brain [J].

Thickbroom, GW ;

Byrnes, ML ;

Blacker, DJ ;

Morris, IT ;

Mastaglia, FL .

BRAIN RESEARCH PROTOCOLS, 2003, 10 (03) :175-180

[40] DEVELOPMENT OF INTELLIGENCE AND MEMORY IN CHILDREN WITH HEMIPLEGIC CEREBRAL-PALSY - THE DELETERIOUS CONSEQUENCES OF EARLY SEIZURES [J].

VARGHAKHADEM, F ;

ISAACS, E ;

VANDERWERF, S ;

ROBB, S ;

WILSON, J .

BRAIN, 1992, 115 :315-329

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