The diagnostic value of β-catenin immunohistochemistry

被引：36

作者：

Montgomery, E

Folpe, AL

机构：

[1] Johns Hopkins Univ Hosp, Dept Pathol, Baltimore, MD 21231 USA

[2] Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA

来源：

ADVANCES IN ANATOMIC PATHOLOGY | 2005年 / 12卷 / 06期

关键词：

beta-catenin; colon adenoma; juvenile nasopharyngeal angiofibroma; endometrial carcinoma; pancreatoblastoma; pancreatic; acinar cell carcinoma; solid and pseudopapillary neoplasm; hepatoblastoma; pulmonary blastoma; fibromatosis; immunohistochemistry;

D O I：

10.1097/01.pap.0000194628.58501.71

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

beta-catenin is a 92-kDa protein that binds to the cytoplasmic tail of E-cadherin. It acts in the nucleus to stimulate cell proliferation and is degraded by complexing with the adenomatous polyposis coli gene. When it is mutated, it is ineffectively degraded and results in unchecked proliferative activity that plays a role in a subset of neoplasms. When there are alterations in beta-catenin degradation, it accumulates to a sufficient extent to be detected in the nuclei of tumor cells immunohistochemically, a feature that can be exploited in the differential diagnosis of selected neoplasms. Immunohistochemistry for beta-catenin may be useful in the differential diagnosis of selected tumors of soft tissue, the gastrointestinal tract, including the pancreas, lung, and female genital tract.

引用

页码：350 / 356

页数：7

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