Recent advances in solventless organic reactions: towards benign synthesis with remarkable versatility

被引:569
作者
Cave, GWV
Raston, CL [1 ]
Scott, JL
机构
[1] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England
[2] Monash Univ, Sch Chem, Ctr Green Chem, Clayton, Vic 3800, Australia
关键词
D O I
10.1039/b106677n
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A paradigm shift away from using solvents in organic synthesis as solventless reactions can lead to improved outcomes, and more benign synthetic procedures, in for example aldol condensation reactions, sequential aldol and Michael addition reactions en route to Krohnke type pyridines, reactions leading to 3-carboxycoumarins, benzylidenes, 4-aryl-1,4-dihydropyridines and 2-aryl-1,2,3,4-tetrahydroquinazolines, and oligomerisation reactions for the synthesis of cavitands; kinetic considerations for the reaction of two solids can only be explained if a eutectic melt is formed during the reaction.
引用
收藏
页码:2159 / 2169
页数:11
相关论文
共 130 条
  • [91] ROBERTS BA, IN PRESS GREEN CHEM
  • [92] A reaction of homopiperonyl and of homoveratryl alcohols
    Robinson, GM
    [J]. JOURNAL OF THE CHEMICAL SOCIETY, 1915, 107 : 267 - 276
  • [93] Understanding solid/solid organic reactions
    Rothenberg, G
    Downie, AP
    Raston, CL
    Scott, JL
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (36) : 8701 - 8708
  • [94] Phase diagrams and thermodynamic properties of binary and ternary systems based on nitroaromatic compounds
    Sangster, J
    [J]. JOURNAL OF PHYSICAL AND CHEMICAL REFERENCE DATA, 1997, 26 (02) : 351 - 502
  • [95] Quantitative solid-solid synthesis of azomethines
    Schmeyers, J
    Toda, F
    Boy, J
    Kaupp, G
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1998, (04): : 989 - 993
  • [96] Schmidt J.G., 1880, BER DTSCH CHEM GES, V13, P2342, DOI [10.1002/cber.188001302266, DOI 10.1002/CBER.188001302266]
  • [97] Scott J. I., UNPUB
  • [98] Clean, efficient syntheses of cyclotriveratrylene (CTV) and tris-(O-allyl)CTV in an ionic liquid
    Scott, JL
    MacFarlane, DR
    Raston, CL
    Teoh, CM
    [J]. GREEN CHEMISTRY, 2000, 2 (04) : 123 - 126
  • [99] Solvent-free synthesis of 3-carboxycoumarins
    Scott, JL
    Raston, CL
    [J]. GREEN CHEMISTRY, 2000, 2 (05) : 245 - 247
  • [100] SHELDON RA, 1992, CHEM IND-LONDON, P903