CRF2-4: Isolation of cDNA clones encoding the human and mouse proteins

被引：24

作者：

Gibbs, VC ^{[1
]}

Pennica, D ^{[1
]}

机构：

[1] GENENTECH INC,DEPT MOL ONCOL,S SAN FRANCISCO,CA

来源：

GENE | 1997年 / 186卷 / 01期

关键词：

nucleotide sequence; exon trapping; interferon receptor; YAC;

D O I：

10.1016/S0378-1119(96)00690-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To search for genes which encode human interferon receptor molecules, we applied the technique of exon trapping to human chromosome 21 yeast artificial chromosomes (YACs). A full length cDNA encoding human CRF2-4 was identified which is shown here to be widely expressed in human tissues. The human CRF2-4 cDNA was used as a probe to screen a mouse macrophage cDNA library. A mouse CRF2-4 cDNA was isolated which encodes a 349-amino-acid (aa) polypeptide that is 69% identical at the aa level with its human counterpart. Mouse CRF2-4 is predicted to be another member of the interferon receptor-class II cytokine receptor family.

引用

页码：97 / 101

页数：5

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