Eupatozansins A-C, Sesquiterpene Lactones from Eupatorium chinense var. tozanense

被引:4
作者
Liaw, Chia-Ching [2 ]
Kuo, Yao-Haur [3 ]
Hwang, Tsong-Long [4 ]
Shen, Ya-Ching [1 ]
机构
[1] Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei, Taiwan
[2] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan
[3] Natl Res Inst Chinese Med, Taipei 112, Taiwan
[4] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan
关键词
D O I
10.1002/hlca.200890227
中图分类号
O6 [化学];
学科分类号
0703 [化学];
摘要
Phytochemical investigation of Eupatorium chinense var. tozanense has resulted in the isolation of three new germacranolides, designated as cupatozansins A - C (1-3), along with five known compounds, (5S,6R,7R,8R)-8-angeloyloxy-2-oxoguaia-1(10),3,11(13)-trien-12,6-olide (4), costunolide (5), leptocarpin (6), 2 alpha-hydroxyeupatolide 8-O-angelate (7), and quercetin (8). The structures of the new compounds were identified by 1D and 2D NMR experiments, as well as high-resolution mass spectrometry. The in vitro cytotoxic activities of compunds 1-8 evaluated.
引用
收藏
页码:2115 / 2121
页数:7
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