Novel Betacoronavirus in Dromedaries of the Middle East, 2013

被引：82

作者：

Woo, Patrick C. Y. ^{[1
]}

Lau, Susanna K. P. ^{[1
]}

Wernery, Ulrich ^{[2
]}

Wong, Emily Y. M. ^{[1
]}

Tsang, Alan K. L. ^{[1
]}

Johnson, Bobby ^{[2
]}

Yip, Cyril C. Y. ^{[1
]}

Lau, Candy C. Y. ^{[1
]}

Sivakumar, Saritha ^{[2
]}

Cai, Jian-Piao ^{[1
]}

Fan, Rachel Y. Y. ^{[1
]}

Chan, Kwok-Hung ^{[1
]}

Mareena, Ringu ^{[2
]}

Yuen, Kwok-Yung ^{[1
]}

机构：

[1] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China

[2] Cent Vet Res Lab, Dubai, U Arab Emirates

来源：

EMERGING INFECTIOUS DISEASES | 2014年 / 20卷 / 04期

关键词：

RESPIRATORY SYNDROME CORONAVIRUS; BAT CORONAVIRUS; COMPLETE GENOME; SPIKE PROTEIN; AVIAN CORONAVIRUSES; DIFFERENT GENOTYPES; SARS CORONAVIRUS; REVEALS; INFECTION; SEQUENCE;

D O I：

10.3201/eid2004.131769

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were detected in 52% of 59 dromedary serum samples tested. In an analysis of 3 complete DcCoV UAE-HKU23 genomes, we identified the virus as a betacoronavirus in lineage A1. The DcCoV UAE-HKU23 genome has G+C contents; a general preference for G/C in the third position of codons; a cleavage site for spike protein; and a membrane protein of similar length to that of other betacoronavirus A1 members, to which DcCoV UAE-HKU23 is phylogenetically closely related. Along with this coronavirus, viruses of at least 8 other families have been found to infect camels. Because camels have a close association with humans, continuous surveillance should be conducted to understand the potential for virus emergence in camels and for virus transmission to humans.

引用

页码：560 / 572

页数：13

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