Measles virus-specific antibody levels in Sudanese infants: a prospective study using filter-paper blood samples

被引:8
作者
Ibrahim, SA
Abdallah, A
Saleh, EA
Osterhaus, ADME
De Swart, RL
机构
[1] Erasmus MC, Dept Virol, NL-3000 DR Rotterdam, Netherlands
[2] Univ Khartoum, Dept Paediat, Khartoum, Sudan
关键词
D O I
10.1017/S0950268805004620
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
We conducted a prospective birth cohort study in rural Sudan to assess measles virus (MV)-specific antibody levels at different time points in infancy. Dried blood spots were collected on filter paper at birth (cord blood) and at ages 6, 12 and 24 months (heel-prick). Maternally derived MV-specific antibody levels were high in cord blood samples, but at the age of 6 months had dropped below cut-off values in half of the infants. By extrapolation it was concluded that the current Expanded Programme of Immunization (EPI) target age for measles vaccination of 9 months was an appropriate choice for this area. At the age of 24 months acquired MV-specific antibodies were detected in 65-85% of the cohort, which corresponded well with the 79% of infants reported to be vaccinated by this age. This study demonstrates the usefulness of filter paper blood samples for seroepidemiological studies in developing countries.
引用
收藏
页码:79 / 85
页数:7
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