Endocannabinoid signals in the control of emotion

被引：104

作者：

Lutz, Beat ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Dept Physiol Chem, D-55099 Mainz, Germany

来源：

CURRENT OPINION IN PHARMACOLOGY | 2009年 / 9卷 / 01期

关键词：

ANXIETY-LIKE BEHAVIOR; ACID AMIDE HYDROLASE; CB1 CANNABINOID RECEPTORS; INVERSE AGONIST; REDUCED ANXIETY; CNR1; GENE; SYSTEM; ACTIVATION; EXTINCTION; FEAR;

D O I：

10.1016/j.coph.2008.12.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The appropriate control of emotional responses evoked by environmental stimuli is an important innate mechanism for ensuring quality of life and even for survival. Inappropriate responses and decreased abilities to adjust to changed environmental situations can lead to psychiatric disorders, such as posttraumatic stress disorders, phobia and depression. Endocannabinoid signalling has emerged as one of the regulatory systems of the brain supporting appropriate emotional responses. As various components of the endocannabinoid system have become therapeutic targets, understanding the endocannabinoids' mechanism of action is an important research topic for a rationalized drug design and optimal therapeutic strategies.

引用

页码：46 / 52

页数：7

共 65 条

[31] The endocannabinoid system and extinction learning [J].

Lutz, Beat .

MOLECULAR NEUROBIOLOGY, 2007, 36 (01) :92-101

[32] Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum [J].

Maccarrone, Mauro ;

Rossi, Silvia ;

Bari, Monica ;

De Chiara, Valentina ;

Fezza, Filomena ;

Musella, Alessandra ;

Gasperi, Valeria ;

Prosperetti, Chiara ;

Bernardi, Giorgio ;

Finazzi-Agro, Alessandro ;

Cravatt, Benjamin F. ;

Centonze, Diego .

NATURE NEUROSCIENCE, 2008, 11 (02) :152-159

[33] Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release [J].

Malcher-Lopes, Renato ;

Di, Shi ;

Marcheselli, Victor S. ;

Weng, Feng-Ju ;

Stuart, Christopher T. ;

Bazan, Nicolas G. ;

Tasker, Jeffrey G. .

JOURNAL OF NEUROSCIENCE, 2006, 26 (24) :6643-6650

[34] N-arachidonoyl-dopamine tunes synaptic transmission onto dopaminergic neurons by activating both cannabinoid and vanilloid receptors [J].

Marinelli, Silvia ;

Di Marzo, Vincenzo ;

Florenzano, Fulvio ;

Fezza, Filomena ;

Viscomi, Maria Teresa ;

van der Stelt, Mario ;

Bernardi, Giorgio ;

Molinari, Marco ;

Maccarrone, Mauro ;

Mercuri, Nicola B. .

NEUROPSYCHOPHARMACOLOGY, 2007, 32 (02) :298-308

[35] Reduced anxiety, conditioned fear, and hippocampal long-term Potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice [J].

Marsch, Rudolph ;

Foeller, Elisabeth ;

Rammes, Gerhard ;

Bunck, Mirjam ;

Koessl, Manfred ;

Holsboer, Florian ;

Zieglgaensberger, Walter ;

Landgraf, Rainer ;

Lutz, Beat ;

Wotjak, Carsten T. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (04) :832-839

[36] CB1 cannabinoid receptors and on-demand defense against excitotoxicity [J].

Marsicano, G ;

Goodenough, S ;

Monory, K ;

Hermann, H ;

Eder, M ;

Cannich, A ;

Azad, SC ;

Cascio, MG ;

Gutiérrez, SO ;

van der Stelt, M ;

López-Rodríguez, ML ;

Casanova, E ;

Schütz, G ;

Zieglgänsberger, W ;

Di Marzo, V ;

Behl, C ;

Lutz, B .

SCIENCE, 2003, 302 (5642) :84-88

[37] The endogenous cannabinoid system controls extinction of aversive memories [J].

Marsicano, G ;

Wotjak, CT ;

Azad, SC ;

Bisogno, T ;

Rammes, G ;

Cascio, MG ;

Hermann, H ;

Tang, JR ;

Hofmann, C ;

Zieglgänsberger, W ;

Di Marzo, V ;

Lutz, B .

NATURE, 2002, 418 (6897) :530-534

[38] Anxiolytic Effects in Mice of a Dual Blocker of Fatty Acid Amide Hydrolase and Transient Receptor Potential Vanilloid Type-1 Channels [J].

Micale, Vincenzo ;

Cristino, Luigia ;

Tamburella, Alessandra ;

Petrosino, Stefania ;

Leggio, Gian Marco ;

Drago, Filippo ;

Di Marzo, Vincenzo .

NEUROPSYCHOPHARMACOLOGY, 2009, 34 (03) :593-606

[39] An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters [J].

Moise, Anna M. ;

Eisenstein, Sarah A. ;

Astarita, Giuseppe ;

Piomelli, Daniele ;

Hohmann, Andrea G. .

PSYCHOPHARMACOLOGY, 2008, 200 (03) :333-346

[40] The endocannabinoid system controls key epileptogenic circuits in the hippocampus [J].

Monory, Krisztina ;

Massa, Federico ;

Egertova, Michaela ;

Eder, Matthias ;

Blaudzun, Heike ;

Westenbroek, Ruth ;

Kelsch, Wolfgang ;

Jacob, Wolfgang ;

Marsch, Rudolf ;

Ekker, Marc ;

Long, Jason ;

Rubenstein, John L. ;

Goebbels, Sandra ;

Nave, Klaus-Armin ;

During, Matthew ;

Klugmann, Matthias ;

Woelfel, Barbara ;

Dodt, Hans-Ulrich ;

Zieglgaensberger, Walter ;

Wotjak, Carsten T. ;

Mackie, Ken ;

Elphick, Maurice R. ;

Marsicano, Giovanni ;

Lutz, Beat .

NEURON, 2006, 51 (04) :455-466

← 1 2 3 4 5 6 7 →