Neuroprotection by GDNF in the ischemic brain

被引：96

作者：

Duarte, Emilia P. ^{[1
,2
]}

Curcio, Michele ^{[3
]}

Canzoniero, Lorella M. ^{[3
]}

Duarte, Carlos B. ^{[1
,2
]}

机构：

[1] Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004517 Coimbra, Portugal

[2] Univ Coimbra, Dept Life Sci, P-3004517 Coimbra, Portugal

[3] Univ Sannio, Dept Biol & Environm Sci, Benevento, Italy

来源：

GROWTH FACTORS | 2012年 / 30卷 / 04期

关键词：

Glial cell line-derived neurotrophic factor (GDNF); brain ischemia; neuroprotection; Ret receptors; NCAM; CEREBRAL-ARTERY OCCLUSION; TRANSIENT FOREBRAIN ISCHEMIA; NEUROTROPHIC FACTOR PROTECTS; MESENCHYMAL STEM-CELLS; APOPTOSIS-INDUCING FACTOR; ENDOTHELIAL GROWTH-FACTOR; DELAYED NEURONAL DEATH; MEDIATED GENE-TRANSFER; HIPPOCAMPAL SLICE CULTURES; FACTOR-SECRETING CELLS;

D O I：

10.3109/08977194.2012.691478

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The glial cell line-derived neurotrophic factor (GDNF) was first identified as a survival factor for midbrain dopaminergic neurons, but additional studies provided evidences for a role as a trophic factor for other neurons of the central and peripheral nervous systems. GDNF regulates cellular activity through interaction with glycosyl-phosphatidylinositol-anchored cell surface receptors, GDNF family receptor-alpha 1, which might signal through the transmembrane Ret tyrosine receptors or the neural cell adhesion molecule, to promote cell survival, neurite outgrowth, and synaptogenesis. The neuroprotective effect of exogenous GDNF has been shown in different experimental models of focal and global brain ischemia, by local administration of the trophic factor, using viral vectors carrying the GDNF gene and by transplantation of GDNF-expressing cells. These different strategies and the mechanisms contributing to neuroprotection by GDNF are discussed in this review. Importantly, neuroprotection by GDNF was observed even when administered after the ischemic injury.

引用

页码：242 / 257

页数：16

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