An exploration of the association between frailty and muscle fatigue

被引：39

作者：

Theou, Olga ^{[1
]}

Jones, Gareth R. ^{[2
]}

Overend, Tom J. ^{[3
]}

Kloseck, Marita ^{[1
]}

Vandervoort, Anthony A. ^{[3
]}

机构：

[1] Univ Western Ontario, Fac Hlth Sci, Grad Program Hlth & Rehabil Sci, London, ON N6A 5B9, Canada

[2] Univ British Columbia, Fac Hlth & Social Dev, Kelowna, BC V1V 1V7, Canada

[3] Univ Western Ontario, Fac Hlth Sci, Sch Phys Therapy, London, ON, Canada

来源：

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM | 2008年 / 33卷 / 04期

关键词：

frailty; muscle fatigue; exercise intolerance; aging; physical activity; sarcopenia;

D O I：

10.1139/H08-058

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Frailty is increasingly recognized as a geriatric syndrome that shares common biomedical determinants with rapid muscle fatigue: aging, disease, inflammation, physical inactivity, malnutrition, hormone deficiencies, subjective fatigue, and changes in neuromuscular function and structure. In addition, there is an established relationship between muscle fatigue and core elements of the cycle of frailty as proposed by Fried and colleagues (sarcopenia, neuroendocrine dysregulation and immunologic dysfunction, muscle weakness, subjective fatigue, reduced physical activity, low gait speed, and weight loss). These relationships suggest that frailty and muscle fatigue are closely related and that low tolerance for muscular work may be an indicator of frailty phenotype.

引用

页码：651 / 665

页数：15

共 156 条

[31] The effect of age and gender on the relative fatigability of the human adductor pollicis muscle [J].

Ditor, DS ;

Hicks, AL .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2000, 78 (10) :781-790

[32] THE ESTIMATED NUMBERS AND RELATIVE SIZES OF THENAR MOTOR UNITS AS SELECTED BY MULTIPLE POINT STIMULATION IN YOUNG AND OLDER ADULTS [J].

DOHERTY, TJ ;

BROWN, WF .

MUSCLE & NERVE, 1993, 16 (04) :355-366

[33] Aging and sarcopenia [J].

Doherty, TJ .

JOURNAL OF APPLIED PHYSIOLOGY, 2003, 95 (04) :1717-1727

[34] EFFECTS OF MOTOR UNIT LOSSES ON STRENGTH IN OLDER MEN AND WOMEN [J].

DOHERTY, TJ ;

VANDERVOORT, AA ;

TAYLOR, AW ;

BROWN, WF .

JOURNAL OF APPLIED PHYSIOLOGY, 1993, 74 (02) :868-874

[35] EFFECTS OF AGING ON THE MOTOR UNIT - A BRIEF REVIEW [J].

DOHERTY, TJ ;

VANDERVOORT, AA ;

BROWN, WF .

CANADIAN JOURNAL OF APPLIED PHYSIOLOGY-REVUE CANADIENNE DE PHYSIOLOGIE APPLIQUEE, 1993, 18 (04) :331-358

[36] Lymphocyte proliferation in response to acute heavy resistance exercise in women: influence of muscle strength and total work [J].

Dohi, K ;

Mastro, AM ;

Miles, MP ;

Bush, JA ;

Grove, DS ;

Leach, SK ;

Volek, JS ;

Nindl, BC ;

Marx, JO ;

Gotshalk, LA ;

Putukian, M ;

Sebastianelli, WJ ;

Kraemer, WJ .

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2001, 85 (3-4) :367-373

[37] Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women [J].

Ensrud, Kristine E. ;

Ewing, Susan K. ;

Taylor, Brent C. ;

Fink, Howard A. ;

Cawthon, Peggy M. ;

Stone, Katie L. ;

Hillier, Teresa A. ;

Cauley, Jane A. ;

Hochberg, Marc C. ;

Rodondi, Nicolas ;

Tracy, J. Kathleen ;

Cummings, Steven R. .

ARCHIVES OF INTERNAL MEDICINE, 2008, 168 (04) :382-389

[38] Protein nutrition, exercise and aging [J].

Evans, WJ .

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2004, 23 (06) :601S-609S

[39] Effects of exercise programs on falls and mobility in frail and pre-frail older adults: A multicenter randomized controlled trial [J].

Faber, Marjan J. ;

Bosscher, Ruud J. ;

Paw, Marijke J. Chin A. ;

van Wieringen, Piet C. .

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 2006, 87 (07) :885-896

[40] Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: A consensus report [J].

Ferrucci, L ;

Guralnik, JM ;

Studenski, S ;

Fried, LP ;

Cutler, GB ;

Walston, JD .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2004, 52 (04) :625-634

← 1 2 3 4 5 6 7 8 9 10 →