Cellular MRI and its role in stem cell therapy

被引：59

作者：

Arbab, Ali S. ^{[1
]}

Frank, Joseph A. ^{[2
]}

机构：

[1] Henry Ford Hosp, Cellular & Mol Imaging Lab, Dept Radiol, Detroit, MI 48202 USA

[2] NIH, Bethesda, MD 20892 USA

来源：

REGENERATIVE MEDICINE | 2008年 / 3卷 / 02期

关键词：

cellular MRI; ferumoxides-protamine sulfate; magnetic cell labeling; SPIO; stem cell tracking;

D O I：

10.2217/17460751.3.2.199

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Hematopoietic, stromal and organ-specific stem cells are under evaluation for therapeutic efficacy in cell-based therapies of cardiac, neurological and other disorders. It is critically important to track the location of directly transplanted or infused cells that can serve as gene carrier/delivery vehicles for the treatment of disease processes and be able to noninvasively monitor the temporal and spatial homing of these cells to target tissues. Moreover, it is also necessary to determine their engraftment efficiency and functional capability following transplantation. There are various in vivo imaging modalities used to track the movement and incorporation of administered cells. Tagging stem cells with different contrast agents can make these cells probes for different imaging modalities. Recent reports have shown that stem cells labeled with iron oxides can be used as cellular MRI probes demonstrating the cell trafficking to target tissues. In this review, we will discuss the status and future prospect of stem cell tracking by cellular MRI for cell-based therapy.

引用

页码：199 / 215

页数：17

共 192 条

[71] Clinically applicable labeling of mammalian and stem cells by combining; Superparamagnetic iron oxides and transfection agents [J].

Frank, JA ;

Miller, BR ;

Arbab, AS ;

Zywicke, HA ;

Jordan, EK ;

Lewis, BK ;

Bryant, LH ;

Bulte, JWM .

RADIOLOGY, 2003, 228 (02) :480-487

[72] Magnetic intracellular labeling of mammalian cells by combining (FDA-approved) superparamagnetic iron oxide MR contrast agents and commonly used transfection agents [J].

Frank, JA ;

Zywicke, H ;

Jordan, EK ;

Mitchell, J ;

Lewis, BK ;

Miller, B ;

Bryant, LH ;

Bulte, JWM .

ACADEMIC RADIOLOGY, 2002, 9 :S484-S487

[73] Catheter-based in vivo imaging of enzyme activity and gene expression: Feasibility study in mice [J].

Funovics, MA ;

Weissleder, R ;

Mahmood, U .

RADIOLOGY, 2004, 231 (03) :659-666

[74] MRI of intravenously injected bone marrow cells homing to the site of injured arteries [J].

Gao, Fabao ;

Kar, Sourav ;

Zhang, Jiangyang ;

Qiu, Bensheng ;

Walczak, Piotr ;

Larabi, Malika ;

Xue, Rong ;

Frost, Emma ;

Qian, Zhiping ;

Bulte, Jeff W. M. ;

Yang, Xiaoming .

NMR IN BIOMEDICINE, 2007, 20 (07) :673-681

[75]

Genove G, 2005, NAT MED, V11, P450, DOI 10.1038/nm1208

[76] Gadofluorine M uptake in stem cells as a new magnetic resonance imaging tracking method -: An in vitro and in vivo study [J].

Giesel, Frederik Lars ;

Stroick, Mark ;

Griebe, Martin ;

Troester, Helmut ;

von der Lieth, Claus W. ;

Requardt, Martin ;

Rius, Maria ;

Essig, Marco ;

Kauczor, Hans-Ulrich ;

Hennerici, M. G. ;

Fatar, Marc .

INVESTIGATIVE RADIOLOGY, 2006, 41 (12) :868-873

[77] Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model [J].

Gómez-Navarro, J ;

Contreras, JL ;

Arafat, W ;

Jiang, XL ;

Krisky, D ;

Oligino, T ;

Marconi, P ;

Hubbard, B ;

Glorioso, JC ;

Curiel, DT ;

Thomas, JM .

GENE THERAPY, 2000, 7 (01) :43-52

[78] Labeling fibroblasts with biotin-BSA-GdDTPA-FAM for tracking of tumor-associated stroma by fluorescence and MR imaging [J].

Granot, D ;

Kunz-Schughart, LA ;

Neeman, M .

MAGNETIC RESONANCE IN MEDICINE, 2005, 54 (04) :789-797

[79] In vivo Imaging of the systemic recruitment of fibroblasts to the angiogenic rim of ovarian carcinoma tumors [J].

Granot, Dorit ;

Addadi, Yoseph ;

Kalchenko, Vyacheslav ;

Harmelin, Alon ;

Kunz-Schughart, Leoni A. ;

Neeman, Michal .

CANCER RESEARCH, 2007, 67 (19) :9180-9189

[80] Vascular gene delivery of anticoagulants by transplantation of retrovirally-transduced endothelial progenitor cells [J].

Griese, DP ;

Achatz, S ;

Batzlsperger, CA ;

Strauch, UG ;

Grumbeck, B ;

Weil, J ;

Riegger, GAJ .

CARDIOVASCULAR RESEARCH, 2003, 58 (02) :469-477

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