Diclofenac-hydrotalcite: In vitro and in vivo release experiments

被引：20

作者：

Bonina, Francesco Paolo ^{[2
]}

Giannossi, Maria Luigia ^{[1
]}

Medici, Luca ^{[1
]}

Puglia, Carmelo ^{[2
]}

Summa, Vito ^{[1
]}

Tateo, Fabio ^{[3
]}

机构：

[1] CNR, IMAA, I-85050 Potenza, Italy

[2] Univ Catania, Fac Farm, Dipartimento Sci Farmaceut, I-95100 Catania, Italy

[3] Univ Padua, CNR, IGG, Sez Padova,Dipartimento Geosci, I-35137 Padua, Italy

来源：

APPLIED CLAY SCIENCE | 2008年 / 41卷 / 3-4期

关键词：

Diclofenac; Hydrotalcite; Release experiments; Franz cells; Human skin;

D O I：

10.1016/j.clay.2007.10.008

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 [物理化学]; 081704 [应用化学];

摘要：

Solutions of the anti-inflammatory drug diclofenac in ethanol and ethanol-water were prepared and mixed with hydrotalcite and hydrotalcite heated at 500 degrees C. Hydrotalcite pretreated at 500 degrees C showed a higher adsorption of diclofenac. Diclofenac-hydrotalcites were used for in vitro release experiments to evaluate the percutaneous absorption of diclofenac, using sets of eight Franz cells with membranes of stratum corneum epidermis obtained from human skin; a 2% diclofenac hydroalcoholic gel was used for comparison. Hydrotalcite pretreated at 500 degrees C is less suitable for release procedures, despite its higher adsorption capacity, whereas diclofenac adsorbed from ethanolic solution by untreated hydrotalcite presents the most efficient sample and shows the best permeation profiles. This sample was selected for the in vivo experiments. Ten healthy volunteers participated on the in vivo experiments: the diclofenac-hydrotalcite appeared to be useful for an efficient application on human skin as inhibitor of the UV-induced erythemas, also better than the usual gel samples. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：165 / 171

页数：7

共 27 条

[1]

Use of clays as drug delivery systems: Possibilities and limitations [J].