Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides

被引:105
作者
Gordijo, CR [1 ]
Barbosa, CAS [1 ]
Ferreira, AMDC [1 ]
Constantino, VRL [1 ]
Silva, DD [1 ]
机构
[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05513900 Sao Paulo, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
ibuprofen; copper(II); layered double hydroxide; hydrotalcite; adsorption; intercalation; buffering properties; drug transport; vibrational spectroscopy; X-ray diffractometry;
D O I
10.1002/jps.20336
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The immobilization of the NSAID ibuprofen (Hibp) and the Cu(II)-ibp compound on magnesium-aluminum layered double hydroxides (Mg3Al-LDH) is described. Ibuprofen was intercalated on LDHs by three routes (ion exchange, co-precipitation, and reconstruction). The organic drug and the Cu(II)-ibp were also immobilized by adsorption on LDH external surfaces. Materials were characterized by elemental analysis, UV/VIS, FTIR, and Raman spectroscopies, powder X-ray diffractometry (XRD), thermogravimetry, and electronic paramagnetic resonance (EPR). Mg3Al-(ibp)(cop) (30% w/w of drug/material) and Mg3Al-(ibp)(ie) (33%) materials exhibit bilayer arrangements of ibp anions intercalated between the host layers. Mg3Al-(ibP)(rec) and Mg3Al-(ibp)(ads) contain 13% and 6.2% of ibuprofenate, respectively. Mg3Al-(Cu-ibp)(ads) exhibits two Cu centers in different environments interacting with host layers. Pharmacological potential of materials are compared considering the amounts of immobilized drugs and their buffering properties. Mg3Al-(ibp)(ie) and Mg3Al-(ibp)(cop) exhibit poor buffering property, but contain high ibp amounts. Mg3Al-(ibp)(ads) despite having buffering property, contains low amount of ibuprofen. Mg3Al-(ibp)(rec) combines significant amount of immobilized ibp with good buffering property. Mg3Al-(Cu-ibp)(ads), due to the buffering property, may be an interesting new formulation aiming to decrease gastric irritation. (c) 2005 Wiley-Liss, Inc. and the American Pharmacists Association.
引用
收藏
页码:1135 / 1148
页数:14
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