Daily cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

被引:399
作者
Lin, XH [1 ]
Perrimon, N [1 ]
机构
[1] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Genet, Boston, MA 02115 USA
关键词
D O I
10.1038/22343
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The Drosophila wingless gene (wg) encodes a protein of the Wnt family and is a critical regulator in many developmental processes(1). Biochemical studies have indicated that heparan sulphate proteoglycans, consisting of a protein core to which heparan sulphate glycosaminoglycans are attached(2), are important for Wg function(3). Here we show that, consistent with these findings, the Drosophila gene sulfateless (sfl), which encodes a homologue of vertebrate heparan sulphate N-deacetylase/N-sulphotransferase (an enzyme needed for the modification of heparan sulphate) is essential for Wg signalling. We have identified the product of division abnormally delayed (dally), a glycosyl-phosphatidyl inositol (GPI)-linked glypican, as a heparan sulphate proteoglycan molecule involved in Wg signalling, Our results indicate that Daily may act as a co-receptor for Wg, and that Daily, together with Drosophila Frizzled 2, modulates both short- and long-range activities of Wg.
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页码:281 / 284
页数:4
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