Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases

被引：165

作者：

Urig, S

Fritz-Wolf, K

Réau, R

Herold-Mende, C

Tóth, K

Davioud-Charvet, E

Becker, K

机构：

[1] Univ Giessen, Interdisciplinary Res Ctr, D-35392 Giessen, Germany

[2] Max Planck Inst Med Res, Dept Biophys, D-69120 Heidelberg, Germany

[3] Univ Rennes 1, CNRS, UMR 6509, Inst Chem, F-35042 Rennes, France

[4] Univ Heidelberg, Dept Neurosurg, D-69120 Heidelberg, Germany

[5] German Canc Res Ctr, Div Biophys Macromol, D-69120 Heidelberg, Germany

[6] Univ Lille, CNRS, UMR 8525, Lille, France

[7] Univ Heidelberg, Ctr Biochim, D-6900 Heidelberg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 12期

关键词：

enzyme inhibitors; gold; medicinal chemistry; platinum; structure elucidation;

D O I：

10.1002/anie.200502756

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Redox-based chemotherapy: The irreversible inhibition of human glutathione reductase results in a unique S-AuI-S coordination, which was determined crystallographically. The chemotherapeutic potential of phosphine-metal complexes was probed by kinetic analysis of the fast and effective inhibition of redox enzymes as well as by DNA-interaction studies and cell-proliferation tests. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：1881 / 1886

页数：6

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