Identification of pore-forming subunit of P-type calcium channels: An antisense study on rat cerebellar Purkinje cells in culture

被引：41

作者：

Gillard, SE ^{[1
]}

Volsen, SG ^{[1
]}

Smith, W ^{[1
]}

Beattie, RE ^{[1
]}

Bleakman, D ^{[1
]}

Lodge, D ^{[1
]}

机构：

[1] ELI LILLY & CO,LILLY RES CTR LTD,WINDLESHAM GU20 6PH,SURREY,ENGLAND

来源：

NEUROPHARMACOLOGY | 1997年 / 36卷 / 03期

关键词：

calcium channels; calcium channel (P-type); antisense;

D O I：

10.1016/S0028-3908(97)00046-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Treatment of cerebellar neurones in culture with an antisense oligonucleotide (ODN) against alpha(1A), reduced the whole-cell P-type calcium channel current relative to mismatch ODN treated controls (p < 0.001). Therefore, AgaIVA (50 nM) reduced whole-cell calcium current in mismatch and antisense treated cells by 70 +/- 4 and 19 +/- 3%, respectively. (C) 1997 Elsevier Science Ltd.

引用

页码：405 / 409

页数：5

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