Solvent-free preparation of amides from acids and primary amines under microwave irradiation

被引：191

作者：

Perreux, L

Loupy, A

Volatron, F

机构：

[1] Univ Paris 11, CNRS, ICMO, UMR 8615,Lab React Select Supports, F-91405 Orsay, France

[2] Univ Paris 11, Chim Phys Lab, F-91405 Orsay, France

来源：

TETRAHEDRON | 2002年 / 58卷 / 11期

关键词：

amides synthesis; microwave irradiation; solvent-free reaction; polarity; pyrolysis of salts;

D O I：

10.1016/S0040-4020(02)00085-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of amides via pyrolysis of the salts obtained by mixing neat primary amines and carboxylic acids were realized under solvent-free conditions within short times and appreciable yields under microwave activation. The evident specific non-thermal microwave effects are attributed to polarity increase during the course of the reaction, due to development of a dipole in the transition state. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2155 / 2162

页数：8

共 37 条

[1] ABRAMOVITCH RA, 1991, ORG PREP PROCED INT, V23, P685
[2] Improved microwave oven synthesis of amides and imides promoted by imidazole; Convenient transport agent preparation
Baldwin, BW
Hirose, T
Wang, ZH
[J]. CHEMICAL COMMUNICATIONS, 1996, (23) : 2669 - 2670
[3] THE CONVERSION OF CARBOXYLIC-ACIDS TO AMIDES VIA TIN(II) REAGENTS
BURNELLCURTY, C
ROSKAMP, EJ
[J]. TETRAHEDRON LETTERS, 1993, 34 (33) : 5193 - 5196
[4] MICROWAVE-ASSISTED ORGANIC-REACTIONS
CADDICK, S
[J]. TETRAHEDRON, 1995, 51 (38) : 10403 - 10432
[5] Solvent free N-alkyl and N-arylimides preparation from anhydrides catalyzed by TaCl5 silica gel
Chandrasekhar, S
Takhi, M
Uma, G
[J]. TETRAHEDRON LETTERS, 1997, 38 (46) : 8089 - 8092
[6] A CONVENIENT SYNTHESIS OF AMIDES FROM CARBOXYLIC-ACIDS AND PRIMARY AMINES
COSSY, J
PALEGROSDEMANGE, C
[J]. TETRAHEDRON LETTERS, 1989, 30 (21) : 2771 - 2774
[7] Regioselectivity and diastereoselectivity in the phase transfer catalysed Michael addition of 2-phenylcyclohexanone
DiezBarra, E
delaHoz, A
Merino, S
SanchezVerdu, P
[J]. TETRAHEDRON LETTERS, 1997, 38 (13) : 2359 - 2362
[8] ELTSOV AV, 1995, RUSS J GEN CHEM+, V65, P454
[9] Fleming I., 1976, FRONTIER ORBITALS OR, P5
[10] Frisch M.J., 2016, Gaussian 16 Revision C. 01. 2016, V16, P01

← 1 2 3 4 →