Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases

被引：296

作者：

Kumar, Hemant ^{[1
]}

Kim, In-Su ^{[1
]}

More, Sandeep Vasant ^{[1
]}

Kim, Byung-Wook ^{[1
]}

Choi, Dong-Kug ^{[1
]}

机构：

[1] Konkuk Univ, Dept Biotechnol, Coll Biomed & Hlth Sci, Seoul 380701, South Korea

来源：

NATURAL PRODUCT REPORTS | 2014年 / 31卷 / 01期

关键词：

TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT RESPONSE ELEMENT; HEME OXYGENASE-1 EXPRESSION; ERYTHROID 2-RELATED FACTOR-2; DRUG-METABOLIZING-ENZYMES; GLUTATHIONE-S-TRANSFERASE; ACTIVATED PROTEIN-KINASE; TRANSGENIC MOUSE MODEL; INDUCED INFLAMMATORY RESPONSES; PEPTIDE-INDUCED NEUROTOXICITY;

D O I：

10.1039/c3np70065h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidative stress is the central component of chronic diseases. The nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway is vital in the up-regulation of cytoprotective genes and enzymes in response to oxidative stress and treatment with certain dietary phytochemicals. Herein, we classify bioactive compounds derived from natural products that are Nrf2/ARE pathway activators and recapitulate the molecular mechanisms for inducing Nrf2 to provide favorable effects in experimental models of chronic diseases. Moreover, pharmacological inhibition of Nrf2 signalling has emerged as promising strategy against multi-drug resistance thereby improving the treatment efficacy. We have also enlisted natural product-derived inhibitors of Nrf2/ARE pathway.

引用

页码：109 / 139

页数：31

共 441 条

[1] ROS and RNS Signaling in Heart Disorders: Could Antioxidant Treatment Be Successful? [J].

Afanas'ev, Igor .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2011, 2011

[2] Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets [J].

Aggarwal, Bharat B. ;

Sung, Bokyung .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2009, 30 (02) :85-94

[3] Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene [J].

Alam, J ;

Stewart, D ;

Touchard, C ;

Boinapally, S ;

Choi, AMK ;

Cook, JL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (37) :26071-26078

[4] Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury [J].

Aleksunes, Lauren M. ;

Goedken, Michael ;

Manautou, Jose E. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (12) :1937-1940

[5] Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and Its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced Nephrotoxicity [J].

Aleksunes, Lauren M. ;

Goedken, Michael J. ;

Rockwell, Cheryl E. ;

Thomale, Juergen ;

Manautou, Jose E. ;

Klaassen, Curtis D. .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2010, 335 (01) :2-12

[6] Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide [J].

Alía, M ;

Ramos, S ;

Mateos, R ;

Granado-Serrano, AB ;

Bravo, L ;

Goya, L .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2006, 212 (02) :110-118

[7] Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2) [J].

Alía, M ;

Mateos, R ;

Ramos, S ;

Lecumberri, E ;

Bravo, L ;

Goya, L .

EUROPEAN JOURNAL OF NUTRITION, 2006, 45 (01) :19-28

[8] Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans [J].

Almolki, Abdelhamid ;

Guenegou, Armelle ;

Golda, Slawomir ;

Boyer, Laurent ;

Benallaoua, Mourad ;

Amara, Nadia ;

Bachoual, Rafik ;

Lanone, Sophie ;

Dulak, Jozef ;

Burgel, Pierre-Regis ;

El-Benna, Jamel ;

Leynaert, Benedicte ;

Aubier, Michel ;

Boczkowski, Jorge .

AMERICAN JOURNAL OF PATHOLOGY, 2008, 173 (04) :981-992

[9] Myeloperoxidase: Expressing Inflammation and Oxidative Stress in Cardiovascular Disease [J].

Anatoliotakis, Nikolaos ;

Deftereos, Spyridon ;

Bouras, Georgios ;

Giannopoulos, Georgios ;

Tsounis, Dimitrios ;

Angelidis, Christos ;

Kaoukis, Andreas ;

Stefanadis, Christodoulos .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2013, 13 (02) :115-138

[10] Involvement of Nrf2, p38, B-Raf, and nuclear factor-κB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols [J].

Andreadi, CK ;

Howells, LM ;

Atherfold, PA ;

Manson, MM .

MOLECULAR PHARMACOLOGY, 2006, 69 (03) :1033-1040

← 1 2 3 4 5 6 7 8 9 10 →