Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases

被引：302

作者：

Kumar, Hemant ^{[1
]}

Kim, In-Su ^{[1
]}

More, Sandeep Vasant ^{[1
]}

Kim, Byung-Wook ^{[1
]}

Choi, Dong-Kug ^{[1
]}

机构：

[1] Konkuk Univ, Dept Biotechnol, Coll Biomed & Hlth Sci, Seoul 380701, South Korea

来源：

NATURAL PRODUCT REPORTS | 2014年 / 31卷 / 01期

关键词：

TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT RESPONSE ELEMENT; HEME OXYGENASE-1 EXPRESSION; ERYTHROID 2-RELATED FACTOR-2; DRUG-METABOLIZING-ENZYMES; GLUTATHIONE-S-TRANSFERASE; ACTIVATED PROTEIN-KINASE; TRANSGENIC MOUSE MODEL; INDUCED INFLAMMATORY RESPONSES; PEPTIDE-INDUCED NEUROTOXICITY;

D O I：

10.1039/c3np70065h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidative stress is the central component of chronic diseases. The nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway is vital in the up-regulation of cytoprotective genes and enzymes in response to oxidative stress and treatment with certain dietary phytochemicals. Herein, we classify bioactive compounds derived from natural products that are Nrf2/ARE pathway activators and recapitulate the molecular mechanisms for inducing Nrf2 to provide favorable effects in experimental models of chronic diseases. Moreover, pharmacological inhibition of Nrf2 signalling has emerged as promising strategy against multi-drug resistance thereby improving the treatment efficacy. We have also enlisted natural product-derived inhibitors of Nrf2/ARE pathway.

引用

页码：109 / 139

页数：31

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