Considerable differences in vaccine immunogenicities and efficacies related to the diluent used for aluminum hydroxide adjuvant

被引：17

作者：

Lin, Lin ^{[1
]}

Ibrahim, Ashraf S. ^{[1
,2
]}

Avanesian, Valentina ^{[1
]}

Edwards, John E., Jr. ^{[1
,2
]}

Fu, Yue ^{[1
,2
]}

Baquir, Beverlie ^{[1
]}

Taub, Rebecca ^{[1
]}

Spellberg, Brad ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, Los Angeles Biomed Res Inst Harbor, Med Ctr, Div Infect Dis, Torrance, CA 90502 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2008年 / 15卷 / 03期

关键词：

D O I：

10.1128/CVI.00427-07

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We are developing an anticandidal vaccine using the recombinant N terminus of Als3p (rAls3p-N). We report that although more rAls3p-N was bound by aluminum hydroxide diluted in saline than by aluminum hydroxide diluted in phosphate-buffered saline (PBS), its immunogenicity and efficacy were superior in PBS. Thus, protein binding, by itself, may not predict the efficacy of some vaccines with aluminum adjuvants.

引用

页码：582 / 584

页数：3

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