Polyamine Metabolism as Chemotherapeutic Target in Protozoan Parasites

被引：50

作者：

Bacchi, C. J. ^{[1
,2
]}

Yarlett, N. ^{[1
,3
]}

机构：

[1] Pace Univ, Haskins Labs, New York, NY 10038 USA

[2] Pace Univ, Dept Biol, New York, NY 10038 USA

[3] Pace Univ, Dept Chem, New York, NY 10038 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2002年 / 2卷 / 06期

关键词：

D O I：

10.2174/1389557023405549

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Polyamines are essential cell constituents for all organisms. The present review highlights important differences in the synthesis, degradation, and interconversion of polyamines between the protozoan parasites (Trypanosoma brucei, Trypanosoma cruzi, Cryptosporidium parvum and Trichomonas vaginalis) and their mammalian hosts. Approaches include development of mono- and di-substituted polyamine analogs targeting polyamine interconversion, as well as more traditional targeting of synthetic enzymes and related pathways.

引用

页码：553 / 563

页数：11

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