Design of modular non-viral gene therapy vectors

被引：157

作者：

De Laporte, L ^{[1
]}

Rea, JC ^{[1
]}

Shea, LD ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem & Biol Engn, Evanston, IL 60208 USA

来源：

BIOMATERIALS | 2006年 / 27卷 / 07期

关键词：

gene therapy; vector; lipoplex; polyplex; cell trafficking;

D O I：

10.1016/j.biomaterials.2005.09.036

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Gene delivery has numerous potential applications both clinically and for basic science research. Non-viral vectors represent the long-term future of gene therapy and biomaterials are a critical component for the development of efficient delivery systems. Biomaterial development combined with fundamental studies of virus function and cellular processes will enable the molecular level design of modular vectors. Vectors are being developed based on cationic polymers or lipids that contain functional groups to mediate appropriate interactions with the extracellular environment or to interface with specific cellular processes. This review describes recent progress on the development of biomaterials for non-viral vectors and highlights opportunities for future development. Ultimately, efficient vectors will expand the traditional applications of gene therapy within the clinic and may enable numerous other opportunities within diagnostics, biotechnology, and basic science research. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：947 / 954

页数：8

共 54 条

[51] Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers [J].