Discovery in toxicology: Mediation by gene expression array technology

被引：31

作者：

Hamadeh, HK ^{[1
]}

Bushel, P ^{[1
]}

Paules, R ^{[1
]}

Afshari, CA ^{[1
]}

机构：

[1] NIEHS, Res Triangle Pk, NC 27709 USA

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2001年 / 15卷 / 05期

关键词：

toxicogenomics; genomics; toxicology; microarrays; cDNA; single nucleotide polymorphisms; pattern recognition; bioinformatics; gene expression; biomarkers;

D O I：

10.1002/jbt.10006.abs

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Toxicogenomics is a term that represents the merging of toxicology with novel genomics techniques. Data generated in the new-age era of toxicology is relatively complex, requires new bioinformatics tools for adequate interpretation, and allows for the rapid generation of testable hypotheses. Hazard identification and risk assessment processes will advance from the use of genomics techniques, which will lead to greater understanding of mechanism(s) of action of toxicants, development of novel biomarkers of exposure and effect, and better identification of sensitive subpopulations. (C) 2001 John Wiley & Sons, Inc. J Biochem Mol Toxicol 15:231-242, 2001.

引用

页码：231 / 242

页数：12

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