Role of MicroRNAs in Lung Disease

被引：95

作者：

Angulo, Martin ^{[1
,2
]}

Lecuona, Emilia ^{[1
]}

Iasha Sznajder, Jacob ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Div Pulm & Crit Care, Chicago, IL 60611 USA

[2] Univ Republica, Fac Med, Hosp Clin, Dept Fisiopatol, Montevideo, Uruguay

来源：

ARCHIVOS DE BRONCONEUMOLOGIA | 2012年 / 48卷 / 09期

关键词：

MicroRNA; Lung disease; Smoking; Chronic obstructive pulmonary disease; Lung cancer; Pulmonary fibrosis; Lung injury; Asthma; OBSTRUCTIVE PULMONARY-DISEASE; DOWN-REGULATION; REDUCED EXPRESSION; CANCER; SURVIVAL; TARGET; MUSCLE; SPUTUM; CELLS; IDENTIFICATION;

D O I：

10.1016/j.arbres.2012.04.011

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

MicroRNAs (miRNAs) are small non-coding RNA molecules that negatively regulate gene expression. They actively participate in the modulation of important cell physiological processes and are involved in the pathogenesis of lung diseases such as lung cancer, pulmonary fibrosis, asthma and chronic obstructive pulmonary disease. A better understanding of the role that miRNAs play in these diseases could lead to the development of new diagnostic and therapeutic tools. In this review, we discuss the role of some miRNAs in different lung diseases as well as the possible future of these discoveries in clinical applications. (C) 2012 SEPAR. Published by Elsevier Espana, S.L. All rights reserved.

引用

页码：325 / 330

页数：6

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