Water-soluble polysaccharides from the brown alga Eisenia bicyclis: Structural characteristics and antitumor activity

被引：108

作者：

Ermakova, Svetlana ^{[1
]}

Men'shova, Roza ^{[1
]}

Vishchuk, Olesya ^{[1
]}

Kim, Sang-Min ^{[2
]}

Um, Byung-Hun ^{[2
]}

Isakov, Vladimir ^{[1
]}

Zvyagintseva, Tatyana ^{[1
]}

机构：

[1] Russian Acad Sci, Pasific Inst Bioorgan Chem, Far Eastern Branch, Moscow 117901, Russia

[2] Korea Inst Sci & Technol, Gangneung Inst, Kangnung 210340, South Korea

来源：

ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS | 2013年 / 2卷 / 01期

关键词：

Brown alga; Laminarans; Fucoidans; Structure; Anticancer activity; FUCOIDAN; CELLS; LAMINARAN; GLUCAN;

D O I：

10.1016/j.algal.2012.10.002

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Water-soluble polysaccharides were isolated from the brown alga Eisenia bicyclis, which was collected near the coast of the Republic of Korea. The structures of laminaran and fucoidan were investigated. Laminaran from E. bicyclis was determined to be a glucan with beta-(1 -> 6) side chains linked to a beta-(1 -> 3) backbone with relatively few branch points. Based on nuclear magnetic resonance (NMR) data, the ratio of the beta-(1 -> 3) and beta-(1 -> 6) linkages was estimated as 2.6:1. Fucoidan from E. bicyclis was found to contain 1,3-linked fucose residues, some 1,6-, 1,2,6-, 1,4,6-linked galactose residues and traces of mannose and xylose. In addition, the amount of sulfate in fucoidan was 13.2%. Those polysaccharides were non-cytotoxic to human melanoma SK-MEL-28 and colon cancer DLD-1 cells. Laminaran and fucoidan from E. bicyclis inhibited the colony formation of those cells. Therefore, they may have potential as antitumor agents. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：51 / 58

页数：8

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