Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra

被引：135

作者：

Jiang, Hong ^{[1
]}

Li, Lin-Jing ^{[1
]}

Wang, Jun ^{[1
]}

Xie, Jun-Xia ^{[1
]}

机构：

[1] Qingdao Univ, Dept Physiol, Coll Med, State Key Disciplines Physiol Incubat, Qingdao 266071, Peoples R China

来源：

EXPERIMENTAL NEUROLOGY | 2008年 / 212卷 / 02期

基金：

中国国家自然科学基金;

关键词：

ghrelin; GHS-R; dopaminergic neuron; Parkinson's disease; apoptosis;

D O I：

10.1016/j.expneurol.2008.05.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ghrelin, a stomach-derived hormone which induces growth hormone release and promotes positive energy balance, has been reported to inhibit cell apoptosis in endotheliocytes, osteoblasts and cardiocytes. Recent evidence has shown that ghrelin can also inhibit neuronal apoptosis of the hypothalamus and the hippocampus. However, little is known about the effects of ghrelin on the substantia nigra Pars compacta (SNpc) neurons in which ghrelin's receptor, growth hormone secretagogue receptor (GHSR)-1a, is highly expressed. In the present study, we investigated whether ghrelin could Protect nigral dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in mice. We observed that ghrelin, acting through GHS-R 1a, inhibited MPTP-induced dopaminergic neuronal loss in the SNpc as well as dopamine depletion in the striatum. Ghrelin could also reverse the clown-regulated the expression of Bcl-2, up-regulated the expression of Bax, and caspase-3 activation caused by MPTP. This study demonstrated that ghrelin might be a potential Protector of dopaminergic neurons in a therapeutic strategy for Parkinson's disease. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：532 / 537

页数：6

共 43 条

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