Neurodegenerative diseases and oxidative stress

被引：2958

作者：

Barnham, KJ

Masters, CL

Bush, AI ^{[1
]}

机构：

[1] Univ Melbourne, Dept Pathol, Parkville, Vic 3010, Australia

[2] Mental Hlth Res Inst Victoria, Parkville, Vic 3010, Australia

[3] Harvard Univ, Sch Med, Massachusetts Gen Hosp E, Dept Psychiat, Charlestown, MA 02129 USA

[4] Harvard Univ, Sch Med, Lab Oxidat Biol Genet & Aging Res Unit, Charlestown, MA 02129 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2004年 / 3卷 / 03期

关键词：

D O I：

10.1038/nrd1330

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially dangerous, and a complex system of checks and balances exists for utilizing this essential element. Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. The systems in place to cope with the biochemistry of oxygen are complex, and many questions about the mechanisms of oxygen regulation remain unanswered. However, this same complexity provides a number of therapeutic targets, and different strategies, including novel metal - protein attenuating compounds, aimed at a variety of targets have shown promise in clinical studies.

引用

页码：205 / 214

页数：10

共 139 条

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