Metal ion chelation in neurodegenerative disorders

被引：37

作者：

Angel, I ^{[1
]}

Bar, A ^{[1
]}

Horovitz, T ^{[1
]}

Taler, G ^{[1
]}

Krakovsky, M ^{[1
]}

Resnitsky, D ^{[1
]}

Rosenberg, G ^{[1
]}

Striem, S ^{[1
]}

Friedman, JE ^{[1
]}

Kozak, A ^{[1
]}

机构：

[1] D Pharm Ltd, IL-76123 Rehovot, Israel

来源：

DRUG DEVELOPMENT RESEARCH | 2002年 / 56卷 / 03期

关键词：

chelation therapy; brain ischaemia; Alzheimer disease; Parkinson disease; BAPTA; calcium;

D O I：

10.1002/ddr.10083

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Disturbance in metallochemical reactions and metal-protein association are associated with chronic neurodegenerative conditions, such as Alzheimer's and Parkinson's disease, as well as with neurodegeneration triggered by acute cerebral ischaemia. Many neurological diseases have been linked directly or indirectly to perturbed homeostasis of Ca, Fe, Zn, or Cu ions. Consequently, acute or chronic neurodegenerative disorders represent excellent targets for exploiting metal ion chelator approaches.

引用

页码：300 / 309

页数：10

共 68 条

[1] Characterization of copper interactions with Alzheimer amyloid β peptides:: Identification of an attomolar-affinity copper binding site on amyloid β1-42
Atwood, CS
Scarpa, RC
Huang, XD
Moir, RD
Jones, WD
Fairlie, DP
Tanzi, RE
Bush, AI
[J]. JOURNAL OF NEUROCHEMISTRY, 2000, 75 (03) : 1219 - 1233
[2] NEURON-SPECIFIC ENOLASE INCREASES IN CEREBRAL AND SYSTEMIC CIRCULATION FOLLOWING FOCAL ISCHEMIA
BARONE, FC
CLARK, RK
PRICE, WJ
WHITE, RF
FEUERSTEIN, GZ
STORER, BL
OHLSTEIN, EH
[J]. BRAIN RESEARCH, 1993, 623 (01) : 77 - 82
[3] Brain iron pathways and their relevance to Parkinson's disease
Berg, D
Gerlach, M
Youdim, MBH
Double, KL
Zecca, L
Riederer, P
Becker, G
[J]. JOURNAL OF NEUROCHEMISTRY, 2001, 79 (02) : 225 - 236
[4] The versatility and universality of calcium signalling
Berridge, MJ
Lipp, P
Bootman, MD
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (01) : 11 - 21
[5] Structural properties of matrix metalloproteinases
Bode, W
Fernandez-Catalan, C
Tschesche, H
Grams, F
Nagase, H
Maskos, K
[J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 1999, 55 (04) : 639 - 652
[6] Copper and prion disease
Brown, DR
[J]. BRAIN RESEARCH BULLETIN, 2001, 55 (02) : 165 - 173
[7] Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1
Bruijn, LI
Houseweart, MK
Kato, S
Anderson, KL
Anderson, SD
Ohama, E
Reaume, AG
Scott, RW
Cleveland, DW
[J]. SCIENCE, 1998, 281 (5384) : 1851 - 1854
[8] BRYCE SM, 1998, J CEREB BLOOD FLOW M, V18, P1163
[9] RAPID INDUCTION OF ALZHEIMER A-BETA AMYLOID FORMATION BY ZINC
BUSH, AI
PETTINGELL, WH
MULTHAUP, G
PARADIS, MD
VONSATTEL, JP
GUSELLA, JF
BEYREUTHER, K
MASTERS, CL
TANZI, RE
[J]. SCIENCE, 1994, 265 (5177) : 1464 - 1467
[10] Metals and neuroscience
Bush, AI
[J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2000, 4 (02) : 184 - 191

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