Metal ion chelation in neurodegenerative disorders

被引：37

作者：

Angel, I ^{[1
]}

Bar, A ^{[1
]}

Horovitz, T ^{[1
]}

Taler, G ^{[1
]}

Krakovsky, M ^{[1
]}

Resnitsky, D ^{[1
]}

Rosenberg, G ^{[1
]}

Striem, S ^{[1
]}

Friedman, JE ^{[1
]}

Kozak, A ^{[1
]}

机构：

[1] D Pharm Ltd, IL-76123 Rehovot, Israel

来源：

DRUG DEVELOPMENT RESEARCH | 2002年 / 56卷 / 03期

关键词：

chelation therapy; brain ischaemia; Alzheimer disease; Parkinson disease; BAPTA; calcium;

D O I：

10.1002/ddr.10083

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Disturbance in metallochemical reactions and metal-protein association are associated with chronic neurodegenerative conditions, such as Alzheimer's and Parkinson's disease, as well as with neurodegeneration triggered by acute cerebral ischaemia. Many neurological diseases have been linked directly or indirectly to perturbed homeostasis of Ca, Fe, Zn, or Cu ions. Consequently, acute or chronic neurodegenerative disorders represent excellent targets for exploiting metal ion chelator approaches.

引用

页码：300 / 309

页数：10

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