c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

被引：929

作者：

Nie, Zuqin ^{[2
]}

Hu, Gangqing ^{[1
]}

Wei, Gang ^{[1
]}

Cui, Kairong ^{[1
]}

Yamane, Arito ^{[3
]}

Resch, Wolfgang ^{[3
]}

Wang, Ruoning ^{[4
]}

Green, Douglas R. ^{[4
]}

Tessarollo, Lino ^{[5
]}

Casellas, Rafael ^{[3
]}

Zhao, Keji ^{[1
]}

Levens, David ^{[2
]}

机构：

[1] NHLBI, Syst Biol Ctr, Bethesda, MD 20892 USA

[2] NCI, Pathol Lab, Bethesda, MD 20892 USA

[3] NIAMS, Genom & Immun Sect, Bethesda, MD 20892 USA

[4] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

[5] NCI, Neural Dev Sect, FNL, Frederick, MD 21702 USA

来源：

CELL | 2012年 / 151卷 / 01期

关键词：

GRAPHICAL USER-INTERFACE; TRANSCRIPTION FACTOR MYC; LYMPHOMA CELLS; RNA-POLYMERASE; ACTIVATION; MOUSE; FIBROBLASTS; ONCOGENES; REVEALS; GENOME;

D O I：

10.1016/j.cell.2012.08.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The c-Myc HLH-bZIP protein has been implicated in physiological or pathological growth, proliferation, apoptosis, metabolism, and differentiation at the cellular, tissue, or organismal levels via regulation of numerous target genes. No principle yet unifies Myc action due partly to an incomplete inventory and functional accounting of Myc's targets. To observe Myc target expression and function in a system where Myc is temporally and physiologically regulated, the transcriptomes and the genome-wide distributions of Myc, RNA polymerase II, and chromatin modifications were compared during lymphocyte activation and in ES cells as well. A remarkably simple rule emerged from this quantitative analysis: Myc is not an on-off specifier of gene activity, but is a nonlinear amplifier of expression, acting universally at active genes, except for immediate early genes that are strongly induced before Myc. This rule of Myc action explains the vast majority of Myc biology observed in literature.

引用

页码：68 / 79

页数：12

共 58 条

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