IsoDGR-Tagged Albumin: A New v3 Selective Carrier for Nanodrug Delivery to Tumors

被引：32

作者：

Curnis, Flavio ^{[1
]}

Sacchi, Angelina ^{[1
]}

Longhi, Renato ^{[2
]}

Colombo, Barbara ^{[1
]}

Gasparri, Anna ^{[1
]}

Corti, Angelo ^{[1
]}

机构：

[1] Ist Sci San Raffaele, Div Mol Oncol, I-20132 Milan, Italy

[2] CNR, Ist Chim Riconoscimento Mol, I-20131 Milan, Italy

来源：

SMALL | 2013年 / 9卷 / 05期

关键词：

cyclic peptides; human serum albumin; drug delivery; gold nanoparticles; tumor necrosis factors; INTEGRIN; RECEPTOR; ALPHA-V-BETA-8; ANGIOGENESIS; ISOASPARTATE; NGR;

D O I：

10.1002/smll.201202310

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new cyclic peptide containing the isoDGR motif that, after coupling to albumin, selectively binds αvβ3, an integrin overexpressed in the tumor vasculature. IsoDGR-tagged albumin binds tumor vessels and can be exploited as a carrier for the preparation of tumor vasculature-selective nanomedicines, such as gold nanoparticles (Au) carrying tumor necrosis factor α (TNF), a potent vascular damaging agent. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：673 / 678

页数：6

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