Distinct Cytokine Patterns in the Aqueous Humor of Children, Adolescents and Adults with Uveitis

被引：21

作者：

Sijssens, Karen M. ^{[1
]}

Rijkers, Ger T. ^{[2
,3
]}

Rothova, Aniki ^{[1
]}

Stilma, Jan S. ^{[1
]}

de Boer, Joke H. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Ophthalmol, NL-3584 CX Utrecht, Netherlands

[2] St Antonius Hosp, Dept Med Microbiol & Immunol, Nieuwegein, Netherlands

[3] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Pediat Immunol, NL-3584 CX Utrecht, Netherlands

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2008年 / 16卷 / 5-6期

关键词：

age factors; aqueous humor; chemokines; cytokines; uveitis;

D O I：

10.1080/09273940802409969

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To determine the immune mediator profile in relation to age in the aqueous humor (AqH) of patients with uveitis. Methods: AqH of children, adolescents, and adults with uveitis was analyzed for 16 immune mediators. Results: No significant differences were found for IL-8, RANTES, and IP-10. The concentrations of the remaining 13 mediators were significant lower in adults compared with children and adolescents, except for IL-6, which was higher. Conclusions: Various immune mediators are present in higher concentrations in AqH of children and adolescents with different uveitis entities compared with that of adults, except IL-6, which was higher in adults.

引用

页码：211 / 216

页数：6

共 10 条

[1] Multiplex bead immunoassay analysis of aqueous humor reveals distinct cytokine profiles in uveitis [J].

Curnow, SJ ;

Falciani, F ;

Durrani, OM ;

Cheung, CMG ;

Ross, EJ ;

Wloka, K ;

Rauz, S ;

Wallace, GR ;

Salmon, M ;

Murray, PI .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46 (11) :4251-4259

[2] Visual loss in uveitis of childhood [J].

de Boer, J ;

Wulffraat, N ;

Rothova, A .

BRITISH JOURNAL OF OPHTHALMOLOGY, 2003, 87 (07) :879-884

[3] Improved multiplex immunoassay performance in human plasma and synovial fluid following removal of interfering heterophilic antibodies [J].

de Jager, W ;

Prakken, BJ ;

Bijlsma, JWJ ;

Kuis, W ;

Rijkers, GT .

JOURNAL OF IMMUNOLOGICAL METHODS, 2005, 300 (1-2) :124-135

[4] CATARACT-EXTRACTION IN UVEITIS PATIENTS [J].

HOOPER, PL ;

RAO, NA ;

SMITH, RE .

SURVEY OF OPHTHALMOLOGY, 1990, 35 (02) :120-144

[5]

Levy-Clarke Grace A, 2005, Curr Opin Ophthalmol, V16, P281, DOI 10.1097/01.icu.0000177414.79030.32

[6]

MURRAY PI, 1990, INVEST OPHTH VIS SCI, V31, P917

[7] Causes and frequency of blindness in patients with intraocular inflammatory disease [J].

Rothova, A ;

SuttorpvanSchulten, MSA ;

Treffers, WF ;

Kijlstra, A .

BRITISH JOURNAL OF OPHTHALMOLOGY, 1996, 80 (04) :332-336

[8] Cytokines, chemokines and soluble adhesion molecules in aqueous humor of children with uveitis [J].

Sijssens, Karen M. ;

Rijkers, Ger T. ;

Rothova, Aniki ;

Stilma, Jan S. ;

Schellekens, Peter A. W. J. F. ;

de Boer, Joke H. .

EXPERIMENTAL EYE RESEARCH, 2007, 85 (04) :443-449

[9]

TugalTutkun I, 1996, OPHTHALMOLOGY, V103, P375

[10] Diagnostic anterior chamber paracentesis in uveitis: a safe procedure? [J].

VanderLelij, A ;

Rothova, A .

BRITISH JOURNAL OF OPHTHALMOLOGY, 1997, 81 (11) :976-979

← 1 →