Analysis of the complete human mtDNA genome: Methodology and inferences for human evolution

被引：42

作者：

Ingman, M ^{[1
]}

Gyllensten, U ^{[1
]}

机构：

[1] Uppsala Univ, Rudbeck Lab, Dept Genet & Pathol, Med Genet Sect, S-75185 Uppsala, Sweden

来源：

JOURNAL OF HEREDITY | 2001年 / 92卷 / 06期

关键词：

D O I：

10.1093/jhered/92.6.454

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The analysis of mitochondrial DNA (mtDNA) sequences has been a potent tool in our understanding of human evolution. However, almost all studies of human evolution based on mtDNA sequencing have focused on the control region, which constitutes less than 7% of the mitochondrial genome. The rapid development of technology for automated DNA sequencing has made it possible to study the complete mtDNA genomes in large numbers of Individuals, opening the field of mitochondrial population genomics. Here we describe a suitable methodology for determining the complete human mitochondrial sequence and the global mtDNA diversity in humans. Also, we discuss the implications of the results with respect to the different hypotheses for the evolution of modern humans.

引用

页码：454 / 461

页数：8

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