The piglet as a model for B cell and immune system development

被引：97

作者：

Butler, J. E. ^{[1
]}

Lager, K. M. ^{[2
]}

Splichal, I. ^{[3
]}

Francis, D. ^{[4
]}

Kacskovics, I. ^{[5
]}

Sinkora, M.

Wertz, N. ^{[1
]}

Sun, J. ^{[6
]}

Zhao, Y. ^{[7
]}

Brown, W. R. ^{[8
]}

DeWald, R. ^{[9
]}

Dierks, S. ^{[8
]}

Muyidermans, S. ^{[10
]}

Lunney, J. K. ^{[11
]}

McCray, P. B. ^{[12
]}

Rogers, C. S. ^{[13
]}

Welsh, M. J. ^{[13
]}

Navarro, P. ^{[14
]}

Klobasa, F. ^{[15
]}

Habe, F. ^{[16
]}

Ramsoondar, J. ^{[17
]}

机构：

[1] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA

[2] ARS, Natl Anim Dis Ctr, USDA, Ames, IA USA

[3] Acad Sci Czech Republ, Inst Microbiol, Novy Hradek, Czech Republic

[4] S Dakota State Univ, Dept Vet Sci, Brookings, SD 57007 USA

[5] Eotvos Lorand Univ, Inst Biol, Dept Immunol, Budapest, Hungary

[6] Wake Forest Univ, Winston Salem, NC 27109 USA

[7] China Agr Univ, Coll Biol Sci, State Key Lab AgroBiotechnol, Beijing 100094, Peoples R China

[8] Abbott Labs, N Chicago, IL 60064 USA

[9] Natl Vet Serv Lab, Ctr Vet Biol, Ames, IA 50010 USA

[10] Free Univ Brussels, Cellular & Mol Immunol Lab, B-1050 Brussels, Belgium

[11] ARS, ANRI, USDA, Beltsville, MD USA

[12] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA

[13] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA

[14] Pioneer Res, Johnston, IA USA

[15] FAL, Inst Fuer Tierzucht Tierenverhalten, Mariensee, Germany

[16] Univ Ljubljana, Zootech Dept, Domzale, Slovenia

[17] Revivicor, Blacksburg, VA USA

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2009年 / 128卷 / 1-3期

关键词：

Swine; Gnotobiotic; Models; Developmental immunology; Review; ANTIBODY REPERTOIRE DEVELOPMENT; RESPIRATORY SYNDROME VIRUS; V-H GENES; MATERNAL-NEONATAL IMMUNOREGULATION; GERM-FREE PIGLETS; ESCHERICHIA-COLI; MONOCLONAL-ANTIBODIES; GNOTOBIOTIC PIGS; BOVINE IMMUNOGLOBULINS; PORCINE IGA;

D O I：

10.1016/j.vetimm.2008.10.321

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ability to identify factors responsible for disease in all species depends on the ability to separate those factors which are environmental from those that are intrinsic. This is particularly important for studies on the development of the adaptive immune response of neonates. Studies on laboratory rodents or primates have been ambiguous because neither the effect of environmental nor maternal factors on the newborn can be controlled in mammals that: (i) transmit potential maternal immunoregulatory factors in utero and (ii) are altricial and cannot be reared after birth without their mothers. Employing the newborn piglet model can address each of these concerns. However, it comes at the price of having first to characterize the immune system of swine and its development. This review focuses on the porcine B cell system, especially on the methods used for its characterization in fetal studies and neonatal piglets. Understanding these procedures is important in the interpretation of the data obtained. Studies on neonatal piglets have (a) provided valuable information on the development of the adaptive immune system, (b) lead to important advances in evolutionary biology, (c) aided our understanding of passive immunity and (d) provided opportunities to use swine to address specific issues in veterinary and biomedical research and immunotherapy. This review summarizes the history of the development of the piglet as a model for antibody repertoire development, thus providing a framework to guide future investigators. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：147 / 170

页数：24

共 175 条

[31] BOVINE IMMUNOGLOBULINS - AN AUGMENTED REVIEW [J].