An unusual matrix of stereocomplementarity in the hydroxylation of monohydroxy fatty acids catalysed by cytochrome P450 from Bacillus megaterium with potential application in biotransformations

被引：15

作者：

Ahmed, F ^{[1
]}

Al-Mutairi, EH

Avery, KL

Cullis, PM

Primrose, WU

Roberts, GCK

Willis, CL

机构：

[1] Univ Leicester, Dept Chem, Leicester LE1 7RH, Leics, England

[2] Univ Leicester, Dept Biochem, Leicester LE1 7RH, Leics, England

[3] Univ Leicester, Ctr Mechanisms Human Tox, Leicester LE1 7RH, Leics, England

[4] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

CHEMICAL COMMUNICATIONS | 1999年 / 20期

关键词：

D O I：

10.1039/a905974a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cytochrome P-450 from Bacillus megaterium catalyses the diastereoselective hydroxylations of 13-hydroxymyristic acid, to predominantly erythro-12,13-dihydroxymyristic acid, and of 12-hydroxymyristic acid to give predominantly threo-12,13-dihydroxymyristic acid, in reactions that are stereocomplementary and with considerable potential application in biotransformations.

引用

页码：2049 / 2050

页数：2

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