Nutritional regulation of leptin in humans

被引:86
作者
Coleman, RA [1 ]
Herrmann, TS [1 ]
机构
[1] Univ N Carolina, Dept Nutr, Chapel Hill, NC 27599 USA
关键词
leptin; hyperinsulinaemic clamp; hexosamine; circadian; diurnal; fasting; insulin; diet; ob ob;
D O I
10.1007/s001250051210
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although leptin was first discussed as an 'adipostat' that regulated food intake in accordance with triglyceride stores, it has become clear that leptin's role is much more complex and that a great many unanswered questions persist. Human studies have not shown that serum leptin concentrations can be changed rapidly by meals. Insulin seems to have a modest but immediate effect in attenuating the morning nadir of serum leptin as well as a greater effect manifested after 4-6 h. These changes in serum leptin, like the decreases that occur with fasting, are not accompanied by corresponding changes in adipose leptin mRNA, suggesting regulation by translational control or changes in the rate of leptin degradation, secretion or clearance. There is convincing evidence that insulin increases leptin synthesis and secretion, probably through an insulin-dependent effect on glucose metabolism. This effect of insulin is possibly mediated by the hexosamine pathway. What adipocytes seem to be communicating to the brain is not how much triglyceride they contain but whether they are currently synthesizing or hydrolysing triglyceride. Confounding many studies is the problem of leptin's diurnal rhythm. Because many studies only measured leptin during its morning nadir or examined the effects of insulin or specific nutrients provided after an overnight fast, important information on regulation may have been lost.
引用
收藏
页码:639 / 646
页数:8
相关论文
共 80 条
[21]   Effects of fasting and glucose infusion on basal and overnight leptin concentrations in normal-weight women [J].
Grinspoon, SK ;
Askari, H ;
Landt, ML ;
Nathan, DM ;
Schoenfeld, DA ;
Hayden, DL ;
Laposata, M ;
Hubbard, J ;
Klibanski, A .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1997, 66 (06) :1352-1356
[22]   WEIGHT-REDUCING EFFECTS OF THE PLASMA-PROTEIN ENCODED BY THE OBESE GENE [J].
HALAAS, JL ;
GAJIWALA, KS ;
MAFFEI, M ;
COHEN, SL ;
CHAIT, BT ;
RABINOWITZ, D ;
LALLONE, RL ;
BURLEY, SK ;
FRIEDMAN, JM .
SCIENCE, 1995, 269 (5223) :543-546
[23]   Multihormonal control of ob gene expression and leptin secretion from cultured human visceral adipose tissue:: Increased responsiveness to glucocorticoids in obesity [J].
Halleux, CM ;
Servais, I ;
Reul, BA ;
Detry, R ;
Brichard, SM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (03) :902-910
[24]   Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy [J].
Hardie, L ;
Trayhurn, P ;
Abramovich, D ;
Fowler, P .
CLINICAL ENDOCRINOLOGY, 1997, 47 (01) :101-106
[25]   Leptin, the hypothalamus and the regulation of adiposity [J].
Harrold, JA ;
Cai, XJ ;
Williams, G .
CURRENT OPINION IN LIPIDOLOGY, 1998, 9 (04) :295-299
[26]   Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1 [J].
Harvey, J ;
McKenna, F ;
Herson, PS ;
Spanswick, D ;
Ashford, MLJ .
JOURNAL OF PHYSIOLOGY-LONDON, 1997, 504 (03) :527-535
[27]   Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: Effects of dietary fat content and sustained weight loss [J].
Havel, PJ ;
KasimKarakas, S ;
Mueller, W ;
Johnson, PR ;
Gingerich, RL ;
Stern, JS .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (12) :4406-4413
[28]   Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats:: reversal by insulin [J].
Havel, PJ ;
Uriu-Hare, JY ;
Liu, T ;
Stanhope, KL ;
Stern, JS ;
Keen, CL ;
Ahrén, B .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 274 (05) :R1482-R1491
[29]   High-fat meals reduce 24-h circulating leptin concentrations in women [J].
Havel, PJ ;
Townsend, R ;
Chaump, L ;
Teff, K .
DIABETES, 1999, 48 (02) :334-341
[30]  
Heimburger O, 1997, J AM SOC NEPHROL, V8, P1423