Rates and extents of antifungal activities of amphotericin B, flucytosine, fluconazole, and voriconazole against Candida lusitaniae determined by microdilution, Etest, and time-kill methods

被引：35

作者：

Ernst, EJ ^{[1
]}

Yodoi, K ^{[1
]}

Roling, EE ^{[1
]}

Klepser, ME ^{[1
]}

机构：

[1] Univ Iowa, Coll Pharm, Iowa City, IA 52242 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 02期

关键词：

D O I：

10.1128/AAC.46.2.578-581.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Amphotericin B, flucytosine, fluconazole, and voriconazole alone and in combination Acre evaluated against isolates of Candida lusitaniae. MICs were determined by broth microdilution and Etest, and time-kill studies were conducted. Amphotericin B resulted in fungicidal activity against most isolates, whereas fluconazole, voriconazole, and flucytosine produced primarily fungistatic activities. The addition of flucytosine to amphotericin B resulted in a faster rate and greater extent of kill for isolates for which the MICs of amphotericin B were elevated.

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页码：578 / 581

页数：4

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