GPI-microdomains:: a role in signalling via immunoreceptors

被引：250

作者：

Horejsi, V

Drbal, K

Cebecauer, M

Cerny, J

Brdicka, T

Angelisová, P

Stockinger, H

机构：

[1] Acad Sci Czech Republ, Inst Mol Genet, CR-14220 Prague 4, Czech Republic

[2] Charles Univ Prague, Fac Sci, Prague, Czech Republic

[3] Univ Vienna, NFI, Vienna Int Res Cooperat Ctr, Inst Immunol, A-1235 Vienna, Austria

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 08期

关键词：

D O I：

10.1016/S0167-5699(99)01489-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Glycosylphosphatidylinositol (GPI)-anchored proteins and glycosphingolipids are assembled on the leukocyte surface within membrane microdomains, which also accommodate a set of cytoplasmic signalling molecules (Src family kinases, G-proteins, linker proteins). Recent results suggest that these membrane specializations mediate not only signal transduction via GPI-proteins and glycolipids but also play important roles in initiation of signalling via immunoreceptors.

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收藏

页码：356 / 361

页数：6

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