Control of proliferation by Bcl-2 family members

被引：64

作者：

Bonnefoy-Berard, N

Aouacheria, A

Verschelde, C

Quemeneur, L

Marcais, A

Marvel, J

机构：

[1] INSERM, Ctr Etude & Rech Virol & Immunol, U503, F-69365 Lyon 07, France

[2] Univ Lyon 1, CNRS, Lab Biometrie & Biol Evolut, UMR 5558, F-69622 Villeurbanne, France

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1644卷 / 2-3期

关键词：

Bcl-2; cell-cycle; p27; NFAT; p130; apoptosis;

D O I：

10.1016/j.bbamcr.2003.10.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The anti-proliferative effect of Bcl-2 acts mainly at the level of the G0/G1 phase of the cell cycle. Deletions and point mutations in the bcl-2 gene show that the anti-proliferative activity of Bcl-2, can in some cases, be dissociated from its anti-apoptotic function. This indicates that the effect of Bcl-2 on cell cycle progression can be a direct effect and not only a consequence of its anti-apoptotic activity. Bcl-2 appears to mediate its anti-proliferative effect by acting on both signal transduction pathways (NFAT, ERK) and on specific cell cycle regulators (p27, p130). (C) 2003 Elsevier B.V. All rights reserved.

引用

收藏

页码：159 / 168

页数：10

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