Temporal and regional expression of Fos-related proteins in response to ischemic injury

被引：20

作者：

Butler, TL ^{[1
]}

Pennypacker, KR ^{[1
]}

机构：

[1] Univ S Florida, Coll Med, Dept Pharmacol & Therapeut, Tampa, FL 33612 USA

来源：

BRAIN RESEARCH BULLETIN | 2004年 / 63卷 / 01期

关键词：

FRA-2; c-Fos; AP-1; MCAO; stroke; neuroprotection;

D O I：

10.1016/j.brainresbull.2003.12.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The AP-1 transcription factor family has been widely studied in the response to ischemic brain injury. The data to date have demonstrated a complex involvement that depends on stimulus, subunit composition and brain region. One member in particular, the Fos-related antigen FRA-2, has demonstrated a potential for controlling neuroprotective gene expression. This study characterized the temporal and regional expression of a variety of proteins following ischemic injury induced by occlusion of the middle cerebral artery in rats. The results demonstrated upregulation of both c-Fos and FRA-2 in penumbral regions that preceded upregulation of the classic injury-associated proteins expressed by astrocytes and microglia and, in the case of FRA-2, appeared to correlate with neuronal survival. A further, previously undescribed, expression of FRA-2 in endothelial cells of the core ischemic region was also demonstrated. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：65 / 73

页数：9

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