Signal transduction and neurosurvival in experimental models of brain injury

被引：14

作者：

Butler, TL ^{[1
]}

Kassed, CA ^{[1
]}

Pennypacker, KR ^{[1
]}

机构：

[1] Univ S Florida, Coll Med, Dept Pharmacol & Therapeut, Neurosci Program, Tampa, FL 33612 USA

来源：

BRAIN RESEARCH BULLETIN | 2003年 / 59卷 / 05期

关键词：

neuron; NF-kappa B; AP-1; growth factor; animal model; signaling pathways;

D O I：

10.1016/S0361-9230(02)00926-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain injury and neurodegenerative disease are linked by their primary pathological consequence-death of neurons. Current approaches for the treatment of neurodegeneration are limited. In this review, we discuss animal models of human brain injury and molecular biological data that have been obtained from their analysis. In particular, signal transduction pathways that are associated with neurosurvival following injury to the brain are presented and discussed. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：339 / 351

页数：13

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