Signal transduction and neurosurvival in experimental models of brain injury

被引：14

作者：

Butler, TL ^{[1
]}

Kassed, CA ^{[1
]}

Pennypacker, KR ^{[1
]}

机构：

[1] Univ S Florida, Coll Med, Dept Pharmacol & Therapeut, Neurosci Program, Tampa, FL 33612 USA

来源：

BRAIN RESEARCH BULLETIN | 2003年 / 59卷 / 05期

关键词：

neuron; NF-kappa B; AP-1; growth factor; animal model; signaling pathways;

D O I：

10.1016/S0361-9230(02)00926-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain injury and neurodegenerative disease are linked by their primary pathological consequence-death of neurons. Current approaches for the treatment of neurodegeneration are limited. In this review, we discuss animal models of human brain injury and molecular biological data that have been obtained from their analysis. In particular, signal transduction pathways that are associated with neurosurvival following injury to the brain are presented and discussed. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：339 / 351

页数：13

共 209 条

[71] Transgenic activation of Ras in neurons promotes hypertrophy and protects from lesion-induced degeneration
Heumann, R
Goemans, C
Bartsch, D
Lingenhöhl, K
Waldmeier, PC
Hengerer, B
Allegrini, PR
Schellander, K
Wagner, EF
Arendt, T
Kamdem, RH
Obst-Pernberg, K
Narz, F
Wahle, P
Berns, H
[J]. JOURNAL OF CELL BIOLOGY, 2000, 151 (07) : 1537 - 1548
[72] HOPE BT, 1994, J NEUROSCI, V14, P4318
[73] Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome
Ikonomidou, C
Bittigau, P
Ishimaru, MJ
Wozniak, DF
Koch, C
Genz, K
Price, MT
Stefovska, V
Hörster, F
Tenkova, T
Dikranian, K
Olney, JW
[J]. SCIENCE, 2000, 287 (5455) : 1056 - 1060
[74] The IKK complex:: an integrator of all signals that activate NF-κB?
Israël, A
[J]. TRENDS IN CELL BIOLOGY, 2000, 10 (04) : 129 - 133
[75] EFFECTS OF NERVE GROWTH-FACTOR ON CATALASE AND GLUTATHIONE-PEROXIDASE IN A HYDROGEN PEROXIDE-RESISTANT PHEOCHROMOCYTOMA SUBCLONE
JACKSON, GR
SAMPATH, D
WERRBACHPEREZ, K
PEREZPOLO, JR
[J]. BRAIN RESEARCH, 1994, 634 (01) : 69 - 76
[76] Microglial activation and β-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice
Jantzen, PT
Connor, KE
DiCarlo, G
Wenk, GL
Wallace, JL
Rojiani, AM
Coppola, D
Morgan, D
Gordon, MN
[J]. JOURNAL OF NEUROSCIENCE, 2002, 22 (06) : 2246 - 2254
[77] MOLECULAR-BIOLOGY OF VERTEBRATE LEARNING - IS C-FOS A NEW BEGINNING
KACZMAREK, L
[J]. JOURNAL OF NEUROSCIENCE RESEARCH, 1993, 34 (04) : 377 - 381
[78] Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis
Kaltschmidt, B
Uherek, M
Wellmann, H
Volk, B
Kaltschmidt, C
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) : 9409 - 9414
[79] CONSTITUTIVE NF-KAPPA-B ACTIVITY IN NEURONS
KALTSCHMIDT, C
KALTSCHMIDT, B
NEUMANN, H
WEKERLE, H
BAEUERLE, PA
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (06) : 3981 - 3992
[80] STIMULATION OF IONOTROPIC GLUTAMATE RECEPTORS ACTIVATES TRANSCRIPTION FACTOR NF-KAPPA-B IN PRIMARY NEURONS
KALTSCHMIDT, C
KALTSCHMIDT, B
BAEUERLE, PA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (21) : 9618 - 9622

← 3 4 5 6 7 8 9 10 11 12 →