Sudden Fetal Death in Intrahepatic Cholestasis of Pregnancy

被引：60

作者：

Lee, Richard H. ^{[1
]}

Incerpi, Marc H. ^{[1
]}

Miller, David A. ^{[1
]}

Pathak, Bhuvan ^{[1
]}

Goodwin, T. Murphy ^{[1
]}

机构：

[1] Univ So Calif, Los Angeles, CA USA

来源：

OBSTETRICS AND GYNECOLOGY | 2009年 / 113卷 / 02期

关键词：

OBSTETRIC CHOLESTASIS; MANAGEMENT;

D O I：

10.1097/AOG.0b013e31818db1c9

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

BACKGROUND: Intrahepatic cholestasis of pregnancy is associated with an increased risk of fetal death. The mechanism of death is unknown. CASES: The first case involved a young primipara with pruritus and a bile acid concentration of 79 mu mol/dL. While undergoing fetal heart rate monitoring, the fetus had a prolonged deceleration resulting in intrauterine death. The second case involved a young multipara with cholestasis who received ursodeoxycholic acid. Her bile acid concentration improved to 13 mu mol/dL. At 34 weeks of gestation, she had uterine contractions with prolonged decelerations resulting in delivery of her fetus with Apgar scores of 0, 0, and 5 at 1, 5, and 10 minutes, respectively. CONCLUSION: Fetal death from intrahepatic cholestasis of pregnancy can be abrupt and not reliably predicted by the characteristics of the fetal heart rate tracing.

引用

页码：528 / 531

页数：4

共 11 条

[1]

Intrahepatic cholestasis of pregnancy: Perinatal outcome associated with expectant management [J].