Fetal death in a patient with intrahepatic cholestasis of pregnancy

被引:54
作者
Sentilhes, Loic
Verspyck, Eric
Pia, Patrick
Marpeau, Loic
机构
[1] Univ Rouen, Dept Obstet & Gynecol, Hop Charles Nicolle, F-76031 Rouen, France
[2] Elbeuf Gen Hosp, Dept Obstet & Gynecol, Elbeuf, France
关键词
D O I
10.1097/01.AOG.0000187951.98401.f7
中图分类号
R71 [妇产科学];
学科分类号
100211 [妇产科学];
摘要
BACKGROUND: Treatment with ursodeoxycholic acid in intrahepatic cholestasis of pregnancy reduces concentration of transaminases and bile acids in maternal serum, and is thought to reduce fetal death. We report a case of fetal death in a patient with intrahepatic cholestasis of pregnancy who had responded well to ursodeoxycholic acid, demonstrated by a low bile level. CASE: A young nulliparous woman presented with intrahepatic cholestasis of pregnancy at 28 weeks of gestation. Transaminases and bile acids decreased after ursodeoxycholic acid administration. The patient was discharged from the hospital until delivery and received biochemical markers and conventional fetal monitoring twice weekly. Due to low bile acid values (< 13 Ul/L) and unfavorable cervix, the patient was followed up expectantly. Fetal death occurred at 39 weeks and 3 days, although cardiotocograph testing results were normal the day before. CONCLUSION: When lung maturity is achieved for patients with intrahepatic cholestasis of pregnancy, delivery should be considered.
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收藏
页码:458 / 460
页数:3
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