Indoleamine 2,3-dioxygenase activity of acute myeloid leukemia cells can be measured from patients' sera by HPLC and is inducible by IFN-γ

被引：85

作者：

Corm, Selim ^{[1
,2
,3
]}

Berthon, Celine ^{[3
]}

Imbenotte, Michel ^{[2
,4
]}

Biggio, Valeria ^{[3
]}

Lhermitte, Michel ^{[2
,4
]}

Dupont, Caroline ^{[3
]}

Briche, Isabelle ^{[3
]}

Quesnel, Bruno ^{[1
,2
,3
]}

机构：

[1] Ctr Hosp & Univ Lille, Serv Malad Sang, F-59037 Lille, France

[2] Univ Lille 2, Inst Federatif Rech 114, Lille, France

[3] Inst Rech Canc Lille, Equipe 3, U837, INSERM, Lille, France

[4] Fac Sci Pharmaceut & Biol, Toxicol Lab, Lille, France

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 03期

关键词：

IDO; AML; Kynurenine; Tryptophan; IFN-gamma; TRYPTOPHAN; INHIBITION;

D O I：

10.1016/j.leukres.2008.06.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The enzyme indoleamine 2,3-dioxygenase (IDO) converts tryptophan to kynurenine, blocking T-cell activation and inducing immunosuppression. In patients with acute myeloid leukemia (AML), the serum kynurenine/tryptophan ratio (Kyn/Trp) was raised, suggesting a higher IDO activity than in healthy people. Patients with higher Kyn/Trp ratios showed lower survival. IDO activity was also detected in AML cells after exposure to IFN-gamma in vitro, suggesting that the higher Kyn/Trp ratio in serum of AML patients might have resulted from stimulated leukemic blast cells. Thus, in AML, the activity of IDO can be easily monitored, providing a tool for future clinical testing of IDO-blocking drugs. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：490 / 494

页数：5

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